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1.
Discoid lupus erythematosus (DLE) is the most common skin manifestation of lupus; however, the molecular mechanisms underlying DLE remain unknown. Therefore, we aimed to identify key differentially expressed genes (DEGs) in discoid lupus skin and investigate their potential pathways.To identify candidate genes involved in the occurrence and development of the disease, we downloaded the microarray datasets and GSE52471 from the Gene Expression Database (GEO). DEGs between discoid lupus skin and normal controls were selected using the GEO2R tool and Venn diagram software ( GSE72535http://bioinformatics.psb.ugent.be/webtools/Venn/). The Database for Annotation, Visualization, and Integrated Discovery (DAVID), Enrichr, and Cytoscape ClueGo were used to analyze the Kyoto Encyclopedia of Gene and Genome pathways and gene ontology. Protein-protein interactions (PPIs) of these DEGs were further assessed using the Search Tool for the Retrieval Interacting Genes version 10.0.Seventy three DEGs were co-expressed in both datasets. DEGs were predominantly upregulated in receptor signaling pathways of the immune response. In the PPI network, 69 upregulated genes were selected. Furthermore, 4 genes (CXCL10, ISG15, IFIH1, and IRF7) were found to be significantly upregulated in the RIG-I-like receptor signaling pathway, from analysis of Enrichr and Cytoscape ClueGo.The results of this study may provide new insights into the potential molecular mechanisms of DLE. However, further experimentation is required to confirm these findings. 相似文献
2.
A Stable Q Compensated Reverse Time Migration Method Based on Excitation Amplitude Imaging Condition 下载免费PDF全文
Qingqing Li Li-Yun Fu Weijia Sun Wei Wei & Wanting Hou 《Communications In Computational Physics》2020,28(1):141-166
The stability and efficiency, especially the stability, are generally concerned
issues in Q compensated reverse time migration (Q-RTM). The instability occurs because of the exponentially boosted high frequency ambient noise during the forward
or backward seismic wavefield propagation. The regularization and low-pass filtering
methods are two effective strategies to control the instability of the wave propagation in Q-RTM. However, the regularization parameters are determined experimentally, and the wavefield cannot be recovered accurately. The low-pass filtering method
cannot balance the selection of cutoff frequency for varying Q values, and may damage
the effective signals, especially when the signal-to-noise ratio (SNR) of the seismic data
is low, the Q-RTM will be a highly unstable process. In order to achieve the purpose
of stability, the selection of cutoff frequency will be small enough, which can cause
great damage to the effective high frequency signals. In this paper, we present a stable Q-RTM algorithm based on the excitation amplitude imaging condition, which can
compensate both the amplitude attenuation and phase dispersion. Unlike the existing Q-RTM algorithms enlarging the amplitude, the exponentially attenuated seismic
wavefield will be used during both the forward and backward wavefield propagation
of Q-RTM. Therefore, the new Q-RTM algorithm is relative stable, even for the low
SNR seismic data. In order to show the accuracy and stability of our stable Q-RTM
algorithm clearly, an example based on Graben model will be illustrated. Then, a realistic BP gas chimney model further demonstrates that the proposed method enjoys
good stability and anti-noise performance compared with the traditional Q-RTM with
amplitude amplification. Compare the Q-RTM images of these two models to the reference images obtained by the acoustic RTM with acoustic seismic data, the new Q-RTM
results match the reference images quite well. The proposed method is also tested
using a field seismic data, the result shows the effectiveness of our proposed method. 相似文献
3.
The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis 总被引:2,自引:0,他引:2
s. m. scott c. h. knowles d. wang † e. yazaki ‡ l. picon § d. l. wingate ‡ & g. lindberg ¶ 《Neurogastroenterology and motility》2006,18(10):927-935
Interdigestive human small bowel motility is characterized by the migrating motor complex (MMC). The aims of this study were to: (i) establish the normal range of variables of the nocturnal jejunal MMC and (ii) incorporate these data in a subsequent meta-analysis. Eighty-one recordings were performed by prolonged (24 h) ambulatory manometry in 51 subjects in two centres. Quantitative analysis was undertaken of 419 Phase III and 332 Phase II episodes. Adjusted mean values of seven variables were calculated using a mixed-effects model. Meta-analysis of pooled published data to generate a reliable 95% reference range was also performed. Adjusted mean values and confidence intervals are presented for all seven variables. Intrasubject variances were large in comparison with intersubject. Meta-analysis of 19 studies (356 pooled patients) meeting inclusion criteria produced wide reference ranges. At least five such ranges are useful for the detection of abnormality in the individual. This is the largest study of normal volunteers presented to date, with ranges for many variables produced using appropriate statistical methodology. A model for definition of abnormality has been proposed. We recommend that these data may be used by investigators in this field as a complement to other existing indicators of small bowel dysmotility. 相似文献
4.
人工流产(简称人流)是各种避孕失败的主要补救措施,目前早孕妇女人流的主要方式有吸刮术与药物流产两种。本文通过对天津市黄河医院意外早孕妇女选择人流方式意向的临床调查研究,探讨现阶段该两种人流方式的可接受性,结果:1000例早孕妇女中选择药物流产(简称药流)者666例(66.6%),吸刮术者334例(33.4%)。本组选择人流方式的理由,其中519例(51.9%)认为药流痛苦少,占第一位,认为手术干脆而选择吸刮术的217例(21.7%),占第二位,其它依次为吸刮术费用低、药流不必手术、吸刮术流产完全、药流不需请假、吸刮术出血时间短、药流安全、吸刮术副作用少、药流保密。药流是近年来使用的流产新方法,本组研究资料及意向选择只反映现阶段早孕妇女的接受状况。 相似文献
5.
$BasicCollegeofmedicalScienes;InstituteofEndemicDiseases 相似文献
6.
缺锌和补锌对运动大鼠锌营养状况的影响 总被引:5,自引:1,他引:4
通过建立大鼠缺锌模型,观察缺锌及补锌对游泳大鼠血清、肝脏锌含量和五种含锌金属酶活性的影响。结果表明:(1)血浆锌浓度和碱性磷酸酶(AKP)活性是评价机体锌缺乏的灵敏指标;(2)血浆AKP活性同时也是评价运动大鼠锌缺乏的较好指标,而血管紧张素I转换酶、酸性α-D-甘露糖苷酶5-核苷酸酶等不太理想;(3)运动时,缺锌大鼠血浆锌金属酶活性多数变化剧烈,表明机体内环境遭受较大破坏。而补锌后上述指标均接近正常水平,说明适量补锌有助于改善机体缺锌状况,维持机体内环境的稳定 相似文献
7.
九十年代中国人群的膳食与营养状况 总被引:84,自引:6,他引:78
九十年代中国人群的膳食与营养状况葛可佑,翟风英,闽怀成,程列,王青,贾凤梅(中国预防医学科学院营养与食品卫生研究所,北京100050)人群的膳食营养状况在一定程度上可以反映一个国家的经济发展和社会文明程度。世界上大多数发达国家及若干发展中国家都在有计... 相似文献
8.
本文对8名受试者在0.25~0.27MPa下进行三种氧剂量暴露后的肺呼吸功能和X线胸片跟踪观察,目的在于验证整体实验功能结果对本室以往肺表面活性物质(PS)物理特性测定结果的符合性。结果表明,氧暴露剂量达到1060UPTD(肺型氧中毒剂量单位)时,对呼吸道粘膜、肺泡内皮细胞可产生一定程度影响,导致FEV1、FEV,%、MMF、V10(呼气流速)显著改变(P<0.05或P<O.01),但在停止暴露后4—12h内上述指标完全恢复。以上与本室以往PS物理特性测定结果相一致。本义肺活量降低程度较Wright(1972)报道的小,X线胸片无异常;因此,间断用氧要达到连续用氧的等效剂量,应对Wright计量法进行一些修正。 相似文献
9.
10.
本组老年脑出血发病率57%,明显高于中、青年组脑出血。首要病因是高血压病,社会环境变迁是老年脑出血的重要因素。CT扫描特点为①型别:壳核出血最多(35.4%)、其次为丘脑(29%)、脑叶(21.4%)、其它型别均低于5%;②血肿量:小量出血最多(68.8%)。预后特点是存活率较高87.2%、死亡率仅12.8%。 相似文献